Phakathi kwama-alloys ethusi, i-cupronickel isetshenziswa kakhulu ekwakheni umkhumbi, i-petroleum, imboni yamakhemikhali, ukwakhiwa, amandla kagesi, izinsimbi ezinembile, imishini yezokwelapha, izinsimbi zomculo kanye neminye imikhakha njengezingxenye zesakhiwo ezimelana nokugqwala. Ngenxa yokumelana nokugqwala okuhle kakhulu nokubunjwa okulula, ukucubungula nokushisela, i-cupronickel nayo inezindawo ezikhethekile zikagesi, ezingasetshenziswa ukwenza izakhi eziphikisayo, izinto ze-thermocouple nezintambo zesinxephezelo. I-curonickel engeyona eyezimboni isetshenziswa kakhulu ukwenza imisebenzi yezandla yokuhlobisa.